HPE ProLiant DL385 Gen11 2U Dual-Socket AMD Accelerated Rack Server with 320 Total Cores, 6TB DDR5 Memory, and PCIe 5.0 Multi-GPU Expansion

The HPE ProLiant DL385 Gen11 is a versatile 2U dual-processor rack server optimized for high-core parallel workloads, large-scale AI inference, video analytics, big data processing, multi-tenant virtualization, cache clusters and mid-tier database services. Built on 4th & 5th Gen AMD EPYC 9004 / 9005 series 5nm processors, this platform delivers industry-leading core density, massive DDR5 memory bandwidth, full PCIe 5.0 I/O, flexible high-density U.3/EDSFF flash storage and robust multi-GPU expansion capability. Supporting both standard air cooling and optional direct liquid cooling (DLC), plus complete enterprise RAS reliability, HPE Silicon Root of Trust security and HPE iLO 6 out-of-band management, the DL385 Gen11 achieves outstanding price-to-performance compared to Intel dual-socket alternatives. It is widely deployed for internet service clusters, smart city visual analysis, private LLM serving, and distributed data center computing, balancing powerful acceleration, expandable storage and low long-term operation costs.

Full Technical Specification Table

Dual AMD EPYC processors deliver up to 320 total cores, delivering exceptional multi-thread throughput for parallel video stream decoding, concurrent AI inference requests and high-concurrency web cache workloads. The AMD platform provides far more cores per dollar than equivalent dual-socket Intel servers, drastically cutting hardware capital expenditure for large-scale cluster deployment. Massive shared L3 cache reduces frequent memory access latency for batch analytics and model serving tasks.

24 RDIMM memory slots scale to a maximum of 6TB high-speed DDR5 memory with full enterprise memory error protection. Operators can load complete large language model weights and massive feature datasets fully inside memory, eliminating repeated disk I/O bottlenecks during continuous 7×24 online service. Hardware ECC and patrol scrubbing automatically isolate transient memory faults to avoid unplanned production downtime.

Flexible front bay options include ultra-dense 48-bay SFF EDSFF/U.3 Gen5 NVMe trays, delivering microsecond-level flash latency for dataset caching, database transaction logs and real-time inference media storage. Universal AnyBay trays support mixed deployment of high-performance NVMe SSDs and low-cost high-capacity HDDs, enabling customized storage tiering to balance performance and total storage expenditure. Hot-swap design allows online capacity expansion without service interruption.

Abundant PCIe Gen5 expansion bandwidth supports up to four double-width high-power data center GPUs, making the DL385 Gen11 a mainstream cost-effective node for mid-scale LLM inference, multi-channel video analytics and lightweight 3D visualization clusters. Separate dual OCP 3.0 mezzanine slots free up PCIe slots for storage accelerators while enabling seamless upgrade to 10GbE/25GbE/100GbE RoCE inter-node networking for low-latency AI cluster communication. Optional direct liquid cooling resolves thermal throttling issues under full GPU sustained load.

Ultra-high efficiency Platinum modular power supplies reduce continuous power consumption for large server fleets, supporting N+1 fault-tolerant configuration to avoid outages caused by single PSU failure. Dual redundant hot-swappable fan modules provide segmented airflow for CPUs, memory banks and GPU cards; standard air cooling meets most data center demands while DLC options are available for deployments with full 4 double-width GPU configurations.

HPE’s built-in Silicon Root of Trust creates unique digital firmware fingerprints validated by the AMD secure processor during every boot cycle, blocking unauthorized malicious firmware injection and rootkit attacks. Integrated TPM 2.0, secure boot and drive encryption deliver full-stack hardware security for sensitive financial, government and AI training data workloads.

Independent iLO 6 out-of-band management operates separately from the server operating system, enabling remote monitoring, diagnosis and maintenance for distributed server fleets without on-site IT visits. Native compatibility with HPE GreenLake and HPE OneView automates mass deployment, firmware patching and resource scheduling for hundreds of DL385 Gen11 nodes, drastically lowering daily manual operation overhead for enterprise IT teams managing mixed AI and database environments.

• 2U Dual-Socket AMD Accelerated Server: Cost-balanced 2-chassis dual EPYC platform optimized for AI inference, big data and high-concurrency web workloads
• iLO 6 (Integrated Lights-Out): HPE exclusive out-of-band remote hardware monitoring and control ASIC
• Silicon Root of Trust: HPE firmware-level hardware security architecture preventing unauthorized firmware tampering
• EDSFF E3.S / U.3 AnyBay: Universal high-speed Gen5 flash drive tray compatible with NVMe, SAS and SATA storage media
• Direct Liquid Cooling (DLC): Optional targeted liquid cooling solution for full high-power GPU configurations
• 80 PLUS Platinum CRPS PSU: Hot-swappable high-efficiency modular power supply supporting N+1 redundant operation
• OCP 3.0 Mezzanine Slot: Modular dedicated expansion port for high-speed cluster network adapters

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2. Front 2.5-inch SFF U.3/EDSFF drive bay close-up (High-density flash storage & dataset caching section)
3. Internal dual-socket CPU, memory & 4 double-width GPU layout diagram (Multi-GPU AI acceleration selling point block)

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3. Core AI & Parallel Compute Performance Section: Display internal CPU & multi-GPU layout diagram below feature text content

Price Overview

The HPE ProLiant DL385 Gen11 dual-socket 2U AMD accelerated rack server delivers cost-effective customizable configurations for AI inference, big data analytics and multi-tenant virtualization clusters. Entry barebone chassis equipped with dual low-core AMD EPYC CPUs, 128GB DDR5 memory and single Platinum PSU start at USD $3,150 / CNY ¥21,800. Standard mainstream inference nodes with mid-tier dual EPYC processors, 1TB DDR5 memory, 24-bay U.3 NVMe flash array and 2 double-width GPUs range from USD $9,800–$19,600. Fully expanded high-concurrency accelerated servers with top-tier 160-core dual EPYC CPUs, maximum 6TB memory, full 48-bay EDSFF NVMe storage, 4 double-width GPUs, N+1 redundant 2200W power, 25GbE OCP networking and optional DLC cooling can exceed USD $27,400. Final quotation varies by CPU core tier, total memory capacity, drive bay layout and flash media, GPU model & quantity, cooling type (air/DLC), power redundancy configuration, high-speed network add-ons, licensed iLO advanced security features, warranty service tiers and large cluster bulk order discounts.