ASUS ESC8000-E12 4U Server: Supports 2x Intel Xeon 6 CPUs, 32x DDR5 DIMMs (Up to 4TB), 8x Dual-Slot GPUs (Up to 600W Each, H200/RTX PRO 6000), 8x 2.5" Drive Bays, and 3+1 Titanium PSUs

ASUS ESC8000-E12: 4U GPU Server with Intel Xeon 6 Processors

Product Overview

The ASUS ESC8000-E12 is a high-density 4U GPU server powered by dual Intel Xeon 6 processors, designed to deliver exceptional performance for demanding AI training, inferencing, and high-performance computing (HPC) workloads . This robust server directly supports up to eight dual-slot GPUs with active or passive cooling configurations, providing flexible scalability through options like NVIDIA NVLink Bridge for seamless performance optimization .

Engineered for modern data centers, the ESC8000-E12 leverages high-bandwidth PCIe 5.0 architecture, faster GPU interconnects, and an optimized thermal design to handle the most demanding AI and compute-intensive applications .

Key Performance Capabilities

Next-Generation Intel Xeon 6 Processors

The ESC8000-E12 harnesses the power of the latest Intel Xeon 6 processor family:

• Dual Intel Xeon 6 processors (LGA 4710 sockets)

• Up to 86 cores per processor – all P-core architecture for maximum computational power

• Max TDP: 350W per socket

• Memory support: 8-channel DDR5 per CPU, up to 6400MHz

High-Capacity DDR5 Memory

Industry-Leading GPU Support

The ESC8000-E12 is purpose-built for intensive GPU-accelerated workloads:

Flexible Storage Configuration

The ESC8000-E12 offers two SKU options for storage flexibility :

All storage is directly connected to the CPU for minimal latency and enhanced speed without occupying storage .

PCIe 5.0 Expansion Architecture

The ESC8000-E12 features a comprehensive PCIe 5.0 expansion architecture with two configuration SKUs :

Networking and I/O

Management and Security

• Management: ASUS Control Center Enterprise (in-band management)

• Remote Management: ASMB12-iKVM for out-of-band BMC management with ASPEED AST2600

• Security: Hardware-level Root-of-Trust solution for enhanced security and control

• Redfish API Support: For automated data center management

Power and Cooling

Detailed Technical Specifications

Key Applications

AI Training and Deep Learning

With support for up to eight NVIDIA H200 GPUs (600W each), the ESC8000-E12 is optimized for large-scale AI model training. GPU, NIC/DPU, and M.2 boot drives are directly connected to the CPU, minimizing latency and maximizing throughput for demanding AI workloads .

AI Inference

The server supports NVIDIA RTX PRO 6000 Blackwell Server Edition GPUs, making it ideal for high-throughput AI inference, agentic AI, and video inference applications .

High-Performance Computing (HPC)

Dual Intel Xeon 6 processors with 86 cores each, 8-channel DDR5-6400 memory, and PCIe 5.0 expansion enable exceptional performance for scientific simulations, computational chemistry, and genomic research.

Data Analytics and Big Data

The combination of high core count, up to 4TB memory capacity, and flexible NVMe storage enables real-time analytics and big data processing.

Virtualization and Cloud Infrastructure

The ESC8000-E12 can be deployed in virtualized environments supporting GPU pass-through for AI workloads in private and public cloud deployments.

Why Choose ASUS ESC8000-E12?

Physical Specifications

Operating Environment

Conclusion

The ASUS ESC8000-E12 represents a significant advancement in 4U GPU server design, combining dual Intel Xeon 6 processors (up to 86 cores each) with 32 DDR5 DIMM slots (up to 4TB at 6400MHz), eight dual-slot GPU support (up to 600W each), PCIe 5.0 expansion, and flexible storage options (up to 6 NVMe drives) in a high-density 4U form factor.

With support for NVIDIA H200, NVIDIA RTX PRO 6000 Blackwell Server Edition, and Intel Gaudi 3 AI accelerators, direct CPU connectivity for GPU, NIC/DPU, and M.2 drives, 3+1 redundant 3200W Titanium power supplies, 10 hot-swappable 8080 fans, and enterprise-grade management (ASUS Control Center, ASMB12-iKVM with AST2600 BMC, Redfish API), this server delivers exceptional performance, reliability, and efficiency for AI training, AI inference, HPC, and data analytics workloads.

Backed by ASUS's tool-less maintenance design, hardware-level Root-of-Trust security, and comprehensive management suite, the ESC8000-E12 is the ideal choice for organizations seeking a powerful, scalable, and future-proof 4U GPU server platform for modern data center and AI infrastructure environments.